An ongoing
personal investigation into Hydroxychloroquine (HCQ), I'm neither in the
"it's harmless!" nor the "it's poison!" camp which seem to
be all political.
It does look
like HCQ+ZINC (with or without azithromycin) is effective to prevent fatal
progressions when taken at first onset of symptoms especially to avoid the
hospital altogether, and convalescent plasma with antibodies donated from
recovered patients is the best treatment in the hospital for advanced
cases. Not that remdesivir junk being thrust into everyone's faces that
is presently riding on some thin "reduces hospitalization duration
slightly" claim.
HCQ is a
powerful ZINC ionophore. To administer it to sick patients without
supplementing ZINC borders on medical malpractice. To (presumably) treat
COVID with HCQ without supplementing ZINC is sabotage (if you are setting up a
drug trial) or murder (if it was done deliberately).
ZINC has a
proven anti-COVID mechanism.
Country doctor
from NY treats with HCQ+ZINC successfully and Trump mentions the
treatment. Fauci and a (corrupt? stupid? both?) medical establishment
then oversees drug trial after trial that test this powerful ZINC ionophpre
given WITHOUT ZINC. Patients in trials die from COVID without any benefit
from ZINC or HCQ. Then HCQ is vilified. Happening in plain sight.
________
Some are
exploring the financial ties between persons vilifying Hydroxychloroquine (HCQ)
and Gilead and that is interesting (yawn)
But there is
another story here that has contributed to many needless deaths in the USA, and
certainly will in the future if journalists do not move to stop it. And it may be that those financial ties are
also associated with wrongful deaths.
Simply the
OMISSION of ZINC given with HCQ in treatment, "suspicious" drug
trials that test HCQ without also giving ZINC and even some HCQ treatment given
today without ZINC. It is possible that
HCQ given BY ITSELF NEVER had any reliable effectiveness with COVID, and
clinical studies are starting to bear this out.
These "zinc-less"
studies have come with a great human cost -- in terms of the patients involved
in them both treated and controls… and time wasted
by even trying this ridiculous no-ZINC option first in a crisis, and now a
politicized public backlash against HCQ that is unfounded because it was never
given a fair trial until recently. And
on into the future as the unfair/broken no-ZINC drug trials continue to steer
doctors and the public.
This is a
difficult issue to describe for we are talking about the absence of
something. For example, even a fair
coverage of HCQ that fails to mention the possible role of zinc's anti-COVID
mechanism and failing to press doctors to describe it -- is nevertheless helping to bury HCQ even
though HCQ+ZINC if given early is the most promising treatment discovered to
date. Zinc's anti-COVID mechanism has
been known since 2010 and HCQ makes the treatment viable.
Consider all
of the HCQ press coverage you have heard to date. How often has the topic of
ZINC arisen? There's the problem.
Chloroquine and Hydroxychloroquine were first tried because they are zinc
ionophores. So why has all the discourse
been about HCQ itself, but seldom if ever ZINC?
Part of the
problem is that like many supplements ZINC by itself has a whole "snake
oil" culture grown around it, and while it has been shown somewhat to help
fight viruses like the common cold, there are so many ridiculous claims out
there doctors feel unscholarly
discussing zinc by itself. When they are
discussing some new drug they are on more comfortable ground.
But what if
that promising new drug does nothing
by itself, but is already known to do
something great in combination with zinc (where it is the zinc brought into the
cells that actually has the anti-viral effect)?
Sadly, they will continue to discuss the wonder drug. They may have done good research and
personally recognize the crucial role of ZINC and would never treat patients
with HCQ without also supplementing ZINC… but unless you ask them about it you
may never hear it mentioned. This is a
tragedy in the making.
Now what if
other doctors, distracted and beset by crisis, hear about this "wonder
drug" from that news story and fail to do the simple research themselves? And are given the chance to administer HCQ
without ZINC, the omission of ZINC stemming from simple ignorance of its
promising mechanism? Some patients might
be fortunate to have high levels of ZINC from other sources. Many will be ZINC-deficient because they are
elderly and the disease has disrupted their lives and what small supplements
they may normally take. To work
effectively this anti-COVID mechanism may require a large amount of ZINC to be
present in the blood, always given with the HCQ.
And I allege
that ZINC has NOT been given to many.
What was by the end of March most probably a comedy of tragic errors of
this kind (just failing to do the research)… by the first week of April becomes
suspicious. Prominent researchers who
should have spoken out against the omission of ZINC in these trials failed to
speak out publicly, and it begins to become sinister. As I put it, through a combination of human
error and suspicious circumstances, practically indistinguishable from evil.
We have an important
milestone in this story that is especially relevant to Fauci's actions in
April. For Fauci is "the" one
you would have expected have done the research and recognize the crucial
importance of ZINC.
But actually
the research was handed to him, on a platter!
At the April 8th press conference Trump astonished many by giving some
very specific details about medical treatment, something presidents seldom do,
TRUMP
4/8/2020: "In addition [to hydroxychloroquine] the azithromycin and ZINC —
they say ZINC — you should add ZINC. Now, it’s all — has to be recommended by
doctors, physicians. But they say ZINC. I want to throw that out there because
that’s where they seem to be having the best result. So you add the ZINC and
the azithromycin."
Mentioning ZINC
five times in one paragraph? Why would ZINC feature so? The person Trump had privately heard from and
maybe even spoken to was probably Dr. Zev Zelenko, a family practitioner in
upstate NY. Zelenko had recently announced results of treating some 350 patients,
some among them very ill, and reported a near 100% recovery rate. Using HCQ
with ZINC, plus azithromycin.
Zelenko had
done his research. And it is out there,
not just embedded in research papers. This March 6 MedCram video explains the
mechanism by which ZINC opposes coronavirus, two timecodes from the same video
are copied below. The step by step explanations are not difficult to follow and
the whole video is worth a watch.
Several of MedCram's subsequent videos about the HCQ mechanism have been
taken down by youtube which is worthy of its own angry email. But this one has escaped the youtube censors,
COVID-19
infection mechanism: https://www.youtube.com/watch?v=Eeh054-Hx1U&t=3m35s
ZINC's effect
to inhibit replication: https://www.youtube.com/watch?v=Eeh054-Hx1U&t=14m33s
On March 23
Zelenko wrote an open public letter to the medical community ( http://www.nunesfarma.com.br/download.php?id=TlRBPQ==
) with a copy to President Trump detailing his successful treatment with
HCQ+ZINC+AZ. To his great credit Zelenko stressed the importance of ZINC in the
letter, alluding to the mechanism described in the video above with these
words,
"We know
that hydroxychloroquine helps Zinc enter the cell. We know that Zinc slows
viral replication within the cell."
Should that
alone be enough to communicate that it is actually ZINC doing the useful work,
with HCQ as just a crucial component to
get ZINC into the cells? Remember, ZINC
taken orally tends to stay in the blood and only enters cells en masse in the
presence of a powerful ZINC ionophore such as HCQ.
On April 7th
Zelenko followed up with a "Mr. President please…" letter ( https://t.co/QJNF0JkLVt?amp=1 )
addressed directly to President Trump re-hashing the treatment and imploring
Trump to issue Executive Orders to remove State obstacles to physicians
attempting to prescribe HCQ to patients.
This April 7th
letter repeated his regimen but did not
stress the importance of ZINC as should have been. But perhaps Zelenko felt it would have been
belaboring the obvious, an echo of medical professionals' reluctance to expound on zinc from all the "snake oil"
surrounding it. That is tragic.
But as we see
24 hours later, someone was
listening. And that someone had read
Zelenko's previous letter also.
TRUMP 4/8/2020
the day after Zelenko's letter:
"In addition [to hydroxychloroquine] the azithromycin and ZINC — they say
ZINC — you should add ZINC. Now, it’s all — has to be recommended by doctors,
physicians. But they say ZINC. I want to throw that out there because that’s where
they seem to be having the best result. So you add the ZINC and the
azithromycin."
Now that we
see Trump's remark in light of in vito
COVID research going back to 2010 describing ZINC's ability to slow or stop
viral replication… and considering Dr. Fauci's considerable experience in
virology…
By April 9
what had Fauci and the medical establishment done? Fauci did oversee the
beginning of a clinical trial whose announcement you can read here ( https://www.nih.gov/news-events/news-releases/nih-clinical-trial-hydroxychloroquine-potential-therapy-covid-19-begins
) WITH NO ZINC.
Followed by
trial after trial of HCQ with NO ZINC.
HCQ by itself, HCQ with azithromycin.
How about HCQ with sugar sprinkles, HCQ with roofing nails and railroad
spikes? Now that you know the extent to
which Zelenko had communicated the importance of ZINC to President Trump
successfully, doesn't that seem a little… unusual?
Fauci's
dismissive public remarks at the time about 'anecdotal' versus 'clinical'
results don't even raise a red flag with me.
But yet there is little excuse if you are launching trials and must try
variations of a drug. Wouldn't you try
the combination that has the greatest claimed efficacy, first?
So it is not
idly that I harbor actual suspicions about Fauci's motives and conduct around
April 9th. At his level of expertise the
omission of ZINC given with ZINC ionophore HCQ might be the type of blunder that ends careers, or even deliberate and criminal.
There is also such a thing as a growing
conspiracy of omission and ignorance.
Something begins to not happen.
Some may begin to notice something crucial that is missing, but everyone
believes it's someone else's job to point it out. Has this happened across the United
States? Are people who 'do the research'
so rare?
Consider what
may have happened already with HCQ drug trials in the USA. Given the query
https://clinicaltrials.gov/ct2/results?term=hydroxychloroquine&cond=covid-19&cntry=US
…we see 206
studies (as of 5/28) of HCQ proposed, in progress or done. We simply add 'zinc'
to the search,
https://clinicaltrials.gov/ct2/results?term=hydroxychloroquine+zinc&cond=covid-19&cntry=US
…only 3
studies, all "new", announced or recruiting.
This is for
hydroxychloroquine, a known zinc ionophore whose most likely anti-COVID
mechanism is actually bestowed by ZINC, and relies on the presence of ZINC --
perhaps in copious amounts -- in a patient.
Here is where
the absence of ZINC becomes surreal,
in these clinical trial announcements.
Everything that is part of the test must be listed, even ZINC. The absence of anything in these study
announcements means it may be either simply not present or its presence would remain
forever unknown and never recorded.
Unless the trial or study is specifically "given with zinc" or "controls for ZINC" there may not be zinc. These trials are at the very least useless or of marginal value in crisis. We see no mention of ZINC in almost all of
these.
What is
happening in the US? I cannot find fault
in Trump aside from a lack of follow-up.
Of course you
cannot rule out the mere presence of ZINC in any actual patient because it is
present in everyone and essential to life.
So there are people out there with ZINC in their blood when they arrive
at the hospital. But is it a sufficient
amount for this treatment? Even failing
to record the various levels of patients' ZINC in the blood and report it as
part of the trial result would seem to be ludicrous!
I'd surely
like to hear a doctor weigh in to say whether testing a ZINC ionophore for
efficacy with no ZINC is ridiculous, ignorant or immoral. But will not hold my breath. And I am wondering also, why aren't more
doctors communicating actual alarm
over this?
If you ask
you'll get some wagon-circling, for sure.
"Zinc? Huh??" (not done the research). "The anti-COVID
ZINC mechanism has been shown in the laboratory but not in patients" (not
true! See below), "we really don't know how it works" (always a
favorite because people love to hand out benefit of doubt), or even the grave
accusation "Zelenko is a fraud!" (not true far as I know), "zinc
is a 'quack' medicine!" (true for some supplement claims, but deflecting
from its proven COVID mechanism).
Fauci's
explanation for NOT seeing trials launched with ZINC on April 9th after Trump's
ZINC remarks would be most interesting of all.
Dr. Zelenko
has gone through some difficult times as a new celebrity. His youtube videos have been taken down, and
one contained some back of the napkin calculations that attempted to
extrapolate the number of COVID cases in his area based on his patient load and
population… which was not such a great idea as his quick estimates embarrassed
the town elders who felt compelled to challenge the numbers publicly. It also turned out that some of the patients
he counted at first were treated with symptoms but had not actually tested
positive at the time he claimed them as COVID patients, due to a shortage of
tests.
There was also
a bizarre affair involving an email [corsi zelenko zelinski] that generated a
strange story in the Times that had the flavor of a smear, in which someone
claimed Zelenko had said that a hospital-approved study he was conducting was
FDA-approved. In light of the fact that the drugs he was using (HCQ+ZINC+AZ)
are FDA-approved for some things, one could see how confusion might arise over
the terms. Exasperated, he has
apologized that he misspoke and is not familiar with all the terms researchers
use.
And most
recently Zelenko has decided to leave the community where he has practiced
medicine for 16 years. The announcement
was sudden but I see no foul deeds in his mishaps, certainly not his stellar
record of COVID treatment. There might
be a separate human interest story in this too.
In a real
"first" hopefully to bring an end to one of the most shameful
episodes in medical history, the FIRST REAL case study of HCQ+ZINC to yield
direct insight into ZINC's effectiveness was FINALLY completed in the United
States Published in May, it pitted
HCQ+ZINC against HCQ alone… involving patients treated between March 2 through
April 5.
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1.full.pdf
"This
study provides the first in vivo evidence that zinc sulfate in combination with
hydroxychloroquine may play a role in therapeutic management for COVID-19. […] In
univariate analyses, zinc sulfate increased the frequency of patients being
discharged home, and decreased the need for ventilation, admission to the ICU,
and mortality or transfer to hospice for patients who were never admitted to
the ICU. After adjusting for the time at which zinc sulfate was added to our
protocol, an increased frequency of being discharged home (OR 1.53, 95% CI
1.12-2.09) reduction in mortality or transfer to hospice remained significant
(OR 0.449, 95% CI 0.271-0.744)."
This PDF is
worth a read. You can check the final table in the PDF for a telling comparison
of ZINC versus NO ZINC with adjusted P-values.
Because it is a case study they had difficulty determining spans of time
during treatments but it does reflect that zinc was given as an integral part
of HCQ treatment for some, and the researchers' statements are confident.
The gist is,
HCQ+ZINC makes it more likely that you will escape the ventilator, the ICU and
perhaps the hospital altogether if treated early.
Not so
surprising, they did not find any evidence that HCQ+ZINC given to advanced
patients in ICU or on a ventilator decreases mortality. The viral replication ZINC prevents has
already occurred at that stage.
So we have ONE
proven effective treatment for COVID-19.
It is HCQ+ZINC+AZ, given early at onset of first symptoms, hopefully without the need for test delays and without the need for hospitalization
altogether.
Just as
Zelenko tried to tell the world on March 23.
Just as Trump
stressed on April 8.
Consider an alternate reality without vitriol
of all things Trump (including
apparently HCQ). How would that April
timeline have played out?
April 8: Trump
'touts' HCQ+ZINC+AZ.
April 9: In
this fantastic reality, Fauci oversees the beginning of trials WITH ZINC. As statistically significant results WITH
ZINC began to manifest, those trials are suspended
almost immediately in favor of just treating patients properly to avoid
needless deaths in the Control Group.
After Trump brought the issue to everyone's attention and they did the research, any attempt to treat
or trial HCQ without ZINC would be greeted by the derisive laughter it deserves.
Especially since the ZINC would not further 'harm' the patients. NO governors would attempt to restrict
prescriptions of HCQ to and so discourage early treatment.
But as it stands today in this Trump-hating
universe…according
to the slim figures available so far (so embarrassing and late!), the final
percentages on the last page of the study linked above that are the ratio of
6.9% (ZINC) and 13.2% (NO ZINC) for Expired/Hospice patients treated outside of
the ICU…
About HALF of
the USA COVID deaths -- just those treated with HCQ alone -- since April 8th
have been needless deaths.
Mount Sinai
Hospital ( https://www.mountsinai.org/files/MSHealth/Assets/HS/About/Coronavirus/MSHS-Treatment-Guidelines-COVID.pdf
) and others have folded under the
no-ZINC HCQ smear campaign and claim to even not be treating with HCQ
anymore. Doctors are terrified to touch
it, patients are terrified of side effects that are rare and no worse than
death. So daily maybe you could add more deaths as the price of this ZINC-less
murder.
I call it
murder. We're gone beyond the purview
granted to simple ignorance by now.
I think there
are several blockbuster stories in all this, and would be elated to see them
investigated.
Thanks for listening.