December 15th, 2024 • 3h 11m
Shownotes
Every new episode of No Agenda is accompanied by a comprehensive list of shownotes curated by Adam while preparing for the show. Clips played by the hosts during the show can also be found here.
M5M
Be on the lookout for wind suck reads in M5M, maybe AI voices
Adam,
A completely irrelevant and frivolous question...
Is it just me, or are you hearing a tremendous amount of people “sucking wind” (taking a breath right after talking, usually exaggerated by breathing in through their teeth) in podcasts and news clips these days? I never used to notice it in the audio clips you guys played in previous years but now its everywhere to my ears?
Is this the new form of vocal fry?
Poor audio compression setting all these podcasters are using?
Maybe newer generation not trained in proper breathing when speaking in long form?
Consider this my JCD Pet Peeve of the day.
Cheers!
D
Big Pharma
GLP1 - The final solution medicare for all BOTG
Hello,
I work at a clinic where GLP-1 drugs are prescribed more and more. I get many interesting studies emailed to me. Here's information that's available for all to read but not much talked about.
I guess this is what medicine's final destination looks like. When life sucks so bad that the majority of he people descends into binges of junk food, alcohol, drugs, gambling and the like, the solution medicine has is not to encourage people to identify the real problem but just give them the drugs that make people lose interest in those problems such as eating...and in life in general.
It seems that that part is considered just an "acceptable" side effect. Yes, as it turns out the blockbuster GLP-1 drugs are powerful inducers of anhedonia (a lack of interest, pleasure or general enjoyment of life). This is not only a core symptom of clinical depression, but is also notoriously hard to treat. BTW SSRI drugs are known to exacerbate rather than treat anhedonia. That little fact should tell you how "antidepressant" those drugs really are.
Back to anhedonia. This is very difficult to treat with existing drugs, losing pleasure/joy in life is one step away from giving up on life and many people attempt suicide after reaching that stage. Of course if something causes anhedonia that doesn't mean that it also causes depression in all cases. However if one digs deeper, the evidence quickly emerges that GLP-1 agonist drugs do in fact drastically increase the risk of ANY major psychiatric disorder, including clinical depression, and of course suicide.
I guess this is how medicine " treats" obesity, by causing people to lose interest in eating and eventually living. That means so many more psychiatric patients and (maybe hopefully?) fewer people overall. Yay for carbon reduction.
And for those unfortunate enough to have used or planning to use these drugs, if anhedonia ends up developing, it may be treatable by raising dopamine or using dopaminergic drugs, which once again suggests that anhedonia is nothing but a symptom of serotonin access, as serotonin is the master inducer of anhedonia.
[RFK Jr. Smeared as Fatphobic for Questioning Weight Loss Drugs | ZeroHedge](https://www.zerohedge.com/news/2024-12-12/ozempic-propaganda-roundup-rfk-jr-smeared-fatphobic-questioning-weight-loss-drugs)
_“**Eli Lilly**, the company that makes the blockbuster weight loss treatment Zepbound, **will start studying its obesity products as treatments for alcohol and drug abuse**, making it the first major drugmaker to do so, **CEO David Ricks said** Tuesday._
_Emerging research suggests that **GLP-1 drugs** — Zepbound is one such treatment — **not only reduce food cravings but may also suppress desires for other substances**. Yet, so far, no pharma companies have tested the therapies specifically in addiction._
_“**These medicines, we think and we’ve aimed to prove, can be useful for other things we don’t think about connected to weight. These are often called anti-hedonics*, so they are reducing that desire cycle**, said Ricks.”_
[The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon like peptide-1 receptor agonist therapy | Scientific Reports (nature.com)](https://www.nature.com/articles/s41598-024-75965-2)
This large community-based cohort study investigates the impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), specifically Liraglutide and Semaglutide, on the risk of developing psychiatric conditions such as depression, anxiety, and suicidal behaviors in patients with obesity. Utilizing post-marketing data, this research compares patients prescribed GLP-1 RAs (cases) with those not taking these medications (controls). The analysis spanned data from January 1, 2015, to December 31, 2023. To minimize selection bias, we employed 1:1 propensity score matching to account for demographic factors such as age, sex, race, and comorbidities. After matching, the study included 162,253 case and control patients. This study showed a significant association between GLP-1 RA treatment and an 98% increased risk of any psychiatric disorders. Notably, patients on GLP-1 RAs exhibited a 195% higher risk of major depression, a 108% increased risk for anxiety, and a 106% elevated risk for suicidal behavior. These findings underscore the critical need for physicians to thoroughly assess patient history before prescribing GLP-1 RAs and highlight the urgent requirement for further prospective clinical trials to fully understand the implications of GLP-1 RA use on mental health in the obese patient population.
[Rapid Treatment of Anhedonia With Pramipexole as Adjunct to Buprenorphine in OUD (psychiatrist.com)](https://www.psychiatrist.com/pcc/rapid-treatment-anhedonia-pramipexole-adjunct-buprenorphine-opioid-use-disorder/)
Depression with significant anhedonia can contribute to the development and complicate the treatment of opioid use disorder (OUD).1–3 Pramipexole, a dopamine receptor agonist with high affinity for D3 receptors and with possible additional anti-inflammatory properties, has been shown to be effective in treating anhedonic depression.4–7 We report a case in which pramipexole rapidly improved depression and anhedonia symptoms in a patient on buprenorphine and an antidepressant.
excerpts
I know it's long but very interesting imho
Tom
The healthcare riots of 2025
Moderna halts RSV vax clinical trial -- it's a disaster, 3x worse than placebo
Compared to the placebo, their mRNA product increased the risk 3 times of catching the disease and also 3 times of having a severe case of it. A disaster that's not going to be covered by the corporate media.
quote:
"In September 2024, Moderna announced that the clinical trial of its mRNA vaccine for respiratory syncytial virus (RSV) in children aged 5–24 months was abruptly halted.
The clinical trial, conducted in the UK and other countries, ended after alarming data suggested that the vaccine might not just fail to prevent severe RSV disease, but could potentially worsen it.
Until now, the data were kept secret.
This week, the Food and Drug Administration (FDA) disclosed that vaccinated children in the trial experienced higher rates of severe RSV compared to those in the placebo group.
The data was striking: 12.5% of vaccinated children developed severe or very severe RSV disease, compared to just 5% in the placebo group.
Moreover, among those who developed symptomatic RSV, 26.3% of vaccinated participants progressed to severe illness, sharply contrasting with the 8.3% in the placebo group.
The FDA, which granted the vaccine Fast Track designation in 2021, said the data have “uncertain implications for the ongoing and future pediatric development of other non-live attenuated RSV vaccines.” "
here:
Moderna’s mRNA vaccine against RSV takes a tumble
the document:
Drones
Drone maker thinks the drones are looking for a nuclear warhead that was shipped from Ukraine
Beware of false prophets they are wolves in sheep's clothing, you will recognize them by their fruit
You can always identify the false prophets by their fruit
NDAA Passes - Drone sightings will now stop
Subtitle B--Drone Security
Sec. 1821. Short title.
Sec. 1822. Definitions.
Sec. 1823. Prohibition on procurement of covered unmanned aircraft
systems from covered foreign entities.
Sec. 1824. Prohibition on operation of covered unmanned aircraft systems
from covered foreign entities.
Sec. 1825. Prohibition on use of Federal funds for procurement and
operation of covered unmanned aircraft systems from covered
foreign entities.
Sec. 1826. Prohibition on use of Government-issued purchase cards to
purchase covered unmanned aircraft systems from covered
foreign entities.
Sec. 1827. Management of existing inventories of covered unmanned
aircraft systems from covered foreign entities.
Sec. 1828. Comptroller General report.
Sec. 1829. Government-wide policy for procurement of unmanned aircraft
systems.
Sec. 1830. State, local, and territorial law enforcement and emergency
service exemption.
Sec. 1831. Study.
Sec. 1832. Exceptions.
Sec. 1833. Sunset.
Subtitle C--Unidentified Anomalous Phenomena
Sec. 1841. Unidentified anomalous phenomena records collection at the
National Archives and Records Administration.
Sec. 1842. Review, identification, transmission to the National
Archives, and public disclosure of unidentified anomalous
phenomena records by government offices.
Sec. 1843. Grounds for postponement of public disclosure of unidentified
anomalous phenomena records.
This was cover for lawmakers so they won't get the heat from the drone industry
Boots-On-The-Ground Police drone stuff
Adam and John!
Baron Anonymous Cop here, with a quick boots on the ground with some additional information regarding the drone conversation from last Thursdays 1721. There has been a concerted effort by American drone manufactures (they do exist) to lobby for Chinese drones to get banned by congress/ regulators. It's always been under the auspice of "national security". Unfortunately, due to the ease of software and "best price" (frankly a better product than any American drones currently) most American public safety agencies use one of the biggest Chinese drone manufacturers, DJI.
Just some background as a cop-dronepilot: I don't spend my time checking girls out like John says I do (he he). The drone is tossed up when looking for dudes jumping fences from stolen cars or helping the fire department find hot spots at house fires. That being said, the easiest no hassle and cheapest for public entities to purchase drones are Chinese made. The typical American made consumer drone ([https://www.adorama.com/alc/blue-suas-drone-list/](https://www.adorama.com/alc/blue-suas-drone-list/)) could cost 1/3 to double the price. They're attempting to be more competitive, but the price and capability of the Chinese product is not matched yet. This initiative has been named "blue label" drones by the government.
From the local government perspectives, we don't know what President Trump is getting behind or will support. Our public safety/ emergency response capability would be smashed if they told all local police and fire that we can't use our current equipment, let alone how much of a waste of money all of that could be. That's not even including all of the hobbyists and private uses drones have (checking out powerlines, photograph, etc.). I've heard it from several helicopter pilots that its really putting them out of business!
Cheers gents!
John let me know if you're in the San Mateo area!
-Baron Anon Cop
Drones over NJ from Drone Dork Will BOTG
Podfather,
Just a few comments on what I’m seeing regarding the NJ drone sightings. The FAA certification you need to fly drones commercially is called a Part 107. I’m actually preparing to get this myself.
RemoteID was just put in place a year or so back which means any drone over 250g needs a remoteID tag which lets the FAA know you are in the area. These come standard on all newer DJI drones. One thing this roll out did was let every other foreign country know that the FAA has no idea what is in the sky unless the hobbyist puts a remoteID tag on their drone. So any country can just fly small UAVs over the US and they have no idea who it is. That said, what I’m seeing footage of doesn’t strike me as foreign. They all have the proper LED indicators on them that you need for FAA compliance. If I were a foreign adversary why would I put any lights at all on a UAV. There are reports of a military arms company that makes drones in that area. It’s fairly obvious it’s them testing stuff and wanting to be hush hush about it. We in the hobby realm have known about the DJI ban for some time now. There are a ton of other companies out there to get components from to build your own. I can also say that no one I know has a remoteID tag on any of their craft. Compliance is low.
Hope that adds some color.
TikTok with Wings
FAA Reauthorization Act of 2018” expires on December 20th
NDAA and Drones from China
NDAA that was passed this week. It contains a requirement for an investigation into “foreign drones” doing no good, and if there’s something found will require the FCC to pull DJI’s radio certification, effectively grounding all their aircraft. I imagine if it comes to that there will be compensation for drone owners, but it won’t be anywhere near enough to cover the cost of an X10 (or any other US built drone). If not then wait for the lawsuits.
Remember that Project Blue Beam projects images that show up on radar
Big Tech AI and the Socials
Agentic AI BOTG
Hi Adam ITM. This is Sir Dodd of the Pears from Friendswood TX. I’m currently a customer success manager for a Salesforce partner. One thing that AI will start to take over (if it hasn’t already) is any support related task (chat, voice, email) or cold calling/emailing (sales development). This will be handled by what they’re calling Agentic AI. Salesforce is already spending a ton of money to sell this product to companies as a way to replace cheap, often outsourced, labor. The results of this technology are really mixed. I would imagine you will hear some stories in the near future detailing how someone manipulated a chat bot into getting free stuff, or how someone was overcharged due to the “agent” mishandling the request and running the payment multiple times. IMO, there will be a ton of awkwardly worded and ineffective emails, texts, as well as calls from these AI agents to all of our inboxes in the near future (unless you use squirrel mail). I would guess this will blow over in about a years time, as most customers can’t even operate and use the software that they currently have, yet alone implement something new. CTOs will hang their future on this and be under pressure to get results. Which in turn means, we get all the slop.
Trump
BlueCry nickname for RJK Jr is Polio Bob
How pissed is everyone going to be when RFK shows they've all been poisoned
North Dakota Oil drying up BOTG Oil Baron
North Dakota declining. Captial efficiency falling meaning the wells are underperforming due to lower production when they drill and frac them. Depletion of the geologic zones is substantial enough to cause us to pause on drilling. We drilled a couple a month ago. Just fracked them last week. So far they’re making 0 oil.
Hot Luigi
Hot Luigi's gun ballistics
John, during 1721 at 22:37, you implied that the gun wasn't rifled.
All pistols are rifled. The "shooter's" pistols would have most definitely been rifled.
It's been long said by ballistics experts that rifling marks left of a bullet are unique to each gun. So, in theory, you can match rifling left on bullets to a barrel of a gun. But I've never had to match rifling to a barrel, so I wouldn't really know.
Also, in the clip you made that comment on, the report said they matched the "casings" to the gun. This would have nothing to do with the rifling, but the impression the chamber and striker makes on the casing and primer.
"3D" printed guns are completely made up of the plastic. The barrel and chamber would still have to be metal. But you can buy just about any gun part anywhere and plug and play.
The part that's "3D printed" is the frame of the gun. The frame of the gun is what's serialized and tracked and must be purchased via an FFL licensed entity. Every other part can be shipped to your door online or even bought in a store without having to fill any paperwork out.
I think John should sit out commenting on anything firearms related. Not John's first fact checked false statement.
Love you mean it
Go Podcasting
Climate Change
North Dakota Oil drying up BOTG Oil Baron
North Dakota declining. Captial efficiency falling meaning the wells are underperforming due to lower production when they drill and frac them. Depletion of the geologic zones is substantial enough to cause us to pause on drilling. We drilled a couple a month ago. Just fracked them last week. So far they’re making 0 oil.
